Here we analyse the evolutionary relationship between Jumonji C (JmjC)- domain-containing proteins and discuss their cellular functions in relation to their . Proteins containing JmjC domain are predicted to be metalloenzymes that adopt The JmjC has been shown to function in a histone demethylation mechanism. The demethylase activity of the JmjC domain-containing proteins is Purification and identification of a histone demethylase activity.a, Histone.
|Published (Last):||13 July 2017|
|PDF File Size:||11.78 Mb|
|ePub File Size:||3.76 Mb|
|Price:||Free* [*Free Regsitration Required]|
Recommend FPrime to your librarian or information manager to request an extended free trial for all users at your institution.
Emerging Roles of JmjC Domain-Containing Proteins.
User comments must be in English, comprehensible and relevant to the article under discussion. F reserves the right to remove any comments that it considers in its absolute discretion to be inappropriate, offensive or otherwise in breach of the Terms and Conditions relating to Materials including Comments. Please disclose any competing interests that might be construed to influence your judgment of the validity or importance of the article, or any recommendation or review.
Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to demetbylation your impartiality.
Consider the following examples, but note that this is not an exhaustive list:. histonw
The use of certain tools provided by this website is subject to additional Terms and Conditions. By clicking “I accept the Terms and Conditions relating to Materials” before you submit your first Material as hereinafter defined you agree to be bound by these conditions every time you submit Material.
A summary of the jmjc-fomain-containing will be automatically included. F does not store cemethylation email addresses. Classified as close New Finding 3. Recommendations Abstract Comments You have reached your article limit. Register for day free trial Registration is free and only takes a moment, or subscribe for unlimited access. Register Already registered with FPrime? Institutional access Recommend FPrime to your librarian or information manager to request an extended free trial for all users at your institution.
Recommend to your librarian. FPrime is an expert-curated resource to help you find the articles of greatest interest and relevance to you. Covalent modification of histones has an important role in regulating chromatin dynamics and transcription. Whereas most covalent histone modifications are reversible, until recently it was unknown whether methyl groups could be actively removed from histones. Using a biochemical assay coupled with chromatography, we have purified a novel JmjC domain-containing protein, JHDM1 JmjC domain-containing histone demethylase 1that specifically demethylates histone H3 at lysine 36 H3-K Thus, we identify the JmjC domain as a novel demethylase signature motif and uncover a protein demethylation mechanism that is conserved from yeast to human.
This entry form currently does not support special characters.
Disclosures Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. Consider the following examples, but note that this is not an exhaustive list: Examples of ‘Non-Financial Competing Interests’ Within the past 4 years, you have held joint grants, published or collaborated with any of the authors of the selected paper.
You have a close personal relationship e. You are a close professional associate of any of the authors e.
JmjC-domain-containing proteins and histone demethylation.
You work at the same institute as any of the authors. You are an Editor for the journal in which the article is published. Examples of ‘Financial Competing Interests’ You expect to receive, or in the past 4 years have received, any of the following from any commercial organization that may gain financially from your submission: You expect to receive, or in the past xnd years have received, shared grant support or other funding with any of the authors.
I am an author of this article. I am a Faculty Member who recommended this article. Neither of the above. This Agreement shall begin on the date hereof. Certain parts of this website offer the opportunity for users to post opinions, information and material including without limitation academic papers and data ‘Material’ in areas of the website.
F does not claim any ownership in the Material that you or any other user posts. F does not screen, edit, publish or review Material prior to its appearance on the website and is not responsible for it. Material does not reflect the views or opinions of F, its agents or affiliates. Any view or opinion expressed in any Material is the view or opinion of the person who posts such view or opinion. Accordingly you may only post Material that you have the right to do so. You may not use the website for any unlawful purpose, including protelns limitation, to upload, post, download or otherwise use any Material that you do not have the copyright owners permission to so upload, post, download or otherwise use, or that would result in you being in breach of these terms and conditions.
F reserves the right to monitor all Material and to remove any Material which it considers in its absolute discretion to be unlawful, inappropriate, offensive or otherwise in breach of these Terms and Conditions. By posting or uploading Material you warrant and represent that: You are entitled to post or upload the Material on the website and have all necessary licenses and consents to do so; the Material does not infringe any intellectual property right, including without limitation copyright, patent or trademark, or other proprietary right of any third party; the Material does not contain any defamatory, libellous, offensive, indecent or otherwise unlawful material or material which eemethylation an invasion of privacy; the Material does not contain any contaminating or destructive features or devices such as viruses, time bombs or coding designed to interrupt, destroy or limit the functionality of this website or any of this website’s user’s computer equipment or software; the Material will not be used to solicit or promote business or custom or present commercial activities or unlawful activity; and the Material is in compliance with all applicable laws.
By posting Material demsthylation grant to F an irrevocable non-exclusive royalty-free license to keep a copy of Material for a reasonable period and as necessary to enable it to comply with its legal obligations.
You hereby agree proteinns indemnify and keep indemnified F, its affiliates, contractors and agents from and against any and all losses including without limitation direct, indirect and consequential losscosts, claims, damages or expenses of whatever nature and howsoever caused arising directly or indirectly from any breach of these Terms and Conditions or arising from the Material posted on this website or content contained in any email sent using the facilities provided by the website by you including without limitation as a result of any infringement of any vemethylation property or other proprietary rights, libel, defamation, obscenity or the Material being otherwise unlawful.
These terms shall be governed by and construed in accordance with English Law. I would like to receive updates when further comments, recommendations, or dissenting dekethylation are publishing on this article. Don’t have an account?