JMJC-DOMAIN-CONTAINING PROTEINS AND HISTONE DEMETHYLATION PDF

Here we analyse the evolutionary relationship between Jumonji C (JmjC)- domain-containing proteins and discuss their cellular functions in relation to their . Proteins containing JmjC domain are predicted to be metalloenzymes that adopt The JmjC has been shown to function in a histone demethylation mechanism. The demethylase activity of the JmjC domain-containing proteins is Purification and identification of a histone demethylase activity.a, Histone.

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Emerging Roles of JmjC Domain-Containing Proteins.

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Recommend to your librarian. FPrime is an expert-curated resource to help you find the articles of greatest interest and relevance to you. Covalent modification of histones has an important role in regulating chromatin dynamics and transcription. Whereas most covalent histone modifications are reversible, until recently it was unknown whether methyl groups could be actively removed from histones. Using a biochemical assay coupled with chromatography, we have purified a novel JmjC domain-containing protein, JHDM1 JmjC domain-containing histone demethylase 1that specifically demethylates histone H3 at lysine 36 H3-K Thus, we identify the JmjC domain as a novel demethylase signature motif and uncover a protein demethylation mechanism that is conserved from yeast to human.

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JmjC-domain-containing proteins and histone demethylation.

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